Category: Ageing

Categories
Ageing Attention Grants Neural dynamics Neural Filters Papers Psychology

New paper in eLife: Brain and behav­iour go sep­a­rate ways in the age­ing listener

Out now in eLife: Oble­ser­lab stats mod­el­ling wiz Sarah Tune togeth­er with Jonas has just pub­lished a seri­ous sta­tis­ti­cal piece of evi­dence on how, in our >N=100 cohort of age­ing lis­ten­ers as fund­ed by the Euro­pean Research Coun­cil, neur­al sig­na­tures of atten­tive lis­ten­ing and the actu­al behav­iour­al out­come a lis­ten­er achieves are not triv­ial­ly con­nect­ed, and in fact are not even pre­dic­tive of one anoth­er  – when we look at the lon­gi­tu­di­nal, two-year tra­jec­to­ry that lis­ten­ers exhib­it in both mea­sures over time.

This study (here is a brief eLife digest on it) pos­es a key­stone result to the ERC project “AUDADAPT”, which we now con­tin­ue with oth­er projects and spin-offs. Many thanks to the large group of Lübeck cit­i­zens who con­tin­ue to sup­port us with their pre­cious time and their brain and behav­iour­al data!

Diese Studie (hier ist eine kurze eLife-Zusam­men­fas­sung) ist ein Schlüs­sel­ergeb­nis des ERC-Pro­jek­ts “AUDADAPT”, das wir nun mit anderen Pro­jek­ten und Spin-offs fort­set­zen. Vie­len Dank an die große Gruppe von Lübeck­er Bürg­erin­nen und Bürg­ern, die uns weit­er­hin mit ihrer kost­baren Zeit und ihren Gehirn- und Ver­hal­tens­dat­en unterstützen!

Categories
Ageing Clinical relevance Papers Psychiatry Publications Uncategorized

New papers in autumn 2023:

Twen­ty-twen­tythree has prob­a­bly not been our most pro­lif­ic year in terms of putting out new research find­ings, which in part is an inter­est­ing delayed con­se­quence of the lab close-down/s­low-down in the pan­dem­ic years. But …

… here we are in autumn 2023 with no less than three fresh find­ings and perspectives:

First, grad­u­ate trainee Frauke Kraus has pub­lished in the Soci­ety for Neu­ro­science out­let eNeu­ro her new find­ings on how moti­va­tion­al state is able to affect lis­ten­ing behav­iour and lis­ten­ing effort (as prox­ied by pupil dilation).

Sec­ond, with our col­leagues from the trans­la­tion­al psy­chi­a­try unit, main­ly Christi­na Andreou and Ste­fan Borg­wardt, Jonas con­tributed to an umbrel­la review on the most like­ly can­di­date pre­dic­tors of an indi­vid­ual at risk tran­si­tion­ing into psy­chosis, in the Jour­nal Trans­la­tion­al Psy­chi­a­try (a spin-off by the mar­ket­ing genius­es at Nature Springer) – the umbrel­la review pos­es a corol­lary of our joint work on hal­lu­ci­na­tions and meta-cog­ni­tion in nor­mal and aber­rant per­cep­tion (stay tuned for more on that one!).

Not least, a new review and a true col­lab­o­ra­tive effort from many neu­ro­science col­leagues here at the Uni­ver­si­ty of Lübeck led by Nico Bun­zeck, we are argu­ing in Neu­ro­science and Biobe­hav­iour­al  Reviews that patho­log­i­cal aging might begin in earnest when and if the typical/healthy func­tion­al com­pen­sa­tion for brain struc­tur­al decline breaks down. Check it out.

Ref­er­ences

Categories
Ageing Attention Auditory Neuroscience Auditory Perception Computational Modelling fMRI Job Offers Neural Oscillations Speech perception

We are hir­ing: two new PhD train­ing oppor­tu­ni­ties start­ing ear­ly next year!

© az1172/ Flickr [CC BY-SA 2.0]

Our two senior researchers, Sarah Tune and Malte Wöst­mann, are hap­py to each announce the open­ing of a three-year PhD posi­tion in the Obleser lab. The posi­tions are part of two recent­ly fund­ed DFG grants, and will fea­ture real­ly excit­ing com­bi­na­tions of behav­iour mod­el­ling and neur­al dynamics!

Sarah’s project will look into how per­cep­tu­al infer­ence changes with age, using speech per­cep­tion as a mod­el sys­tem. It will bring togeth­er behav­iour­al speech per­cep­tion exper­i­ments and func­tion­al neu­roimag­ing, and apply com­pu­ta­tion­al mod­el­ling to link between the two.

For full details, see the offi­cial job ad.

Malte’s project will focus on audi­to­ry atten­tion and its neur­al bases. It will com­bine behav­iour­al and elec­troen­cephalog­ra­phy (EEG) data in younger and old­er adults to inves­ti­gate the neu­ro-cog­ni­tive mech­a­nisms under­ly­ing cap­ture of atten­tion and sup­pres­sion of distraction.

For full details, see the offi­cial job ad.

The appli­ca­tion dead­line (as sin­gle PDF to the email address named in the ad!) is Nov 19, 2023!

Please don’t hes­i­tate to con­tact Sarah or Malte if you have any infor­mal ques­tions about PhD posi­tions and projects. Sarah will also be at APAN and SfN soon, if you feel like chat­ting with her about the position.

We are look­ing for­ward to many inter­est­ing applications!

 

Categories
Ageing Attention Auditory Neuroscience Auditory Perception Auditory Speech Processing EEG / MEG Executive Functions fMRI Grants Hearing Loss Linguistics Neural dynamics Perception Semantics Uncategorized

A grant dou­ble to celebrate

We are hon­oured and delight­ed that the Deutsche Forschungs­ge­mein­schaft has deemed two of our recent appli­ca­tions wor­thy of fund­ing: The two senior researchers in the  lab, Sarah Tune and Malte Wöst­mann, have both been award­ed three-year grant fund­ing for their new projects. Congratulations!

In her 3‑year, 360‑K€ project “How per­cep­tu­al infer­ence changes with age: Behav­iour­al and brain dynam­ics of speech per­cep­tion”, Sarah Tune will explore the role of per­cep­tu­al pri­ors in speech per­cep­tion in the age­ing lis­ten­er. She will main­ly use neur­al and per­cep­tu­al mod­el­ling and func­tion­al neuroimaging.

In his 3‑year, 270‑K€ project “Inves­ti­ga­tion of cap­ture and sup­pres­sion in audi­to­ry atten­tion”, Malte Wöst­mann will con­tin­ue and refine his suc­cess­ful research endeav­our into dis­so­ci­at­ing the role of sup­pres­sive mech­a­nisms in the lis­ten­ing mind and brain, main­ly using EEG and behav­iour­al modelling.

Both of them will soon adver­tise posts for PhD can­di­dates to join us, accord­ing­ly, and to work on these excit­ing projects with Sarah and Malte and the rest of the Oble­ser­lab team

 

Categories
Ageing Auditory Neuroscience Editorial Notes Hearing Loss Psychology

New research fund­ing: joint project with WSA

I am hap­py and hon­oured that one of the lead­ing hear­ing aid devel­op­ers and man­u­fac­tur­ers, Widex Sivan­tos Audi­ol­o­gy (WSA), has agreed with Uni­ver­si­ty of Lübeck to fund 3 more excit­ing years of research at the Obleser lab! We will be joint­ly look­ing at the intri­ca­cies of how age­ing lis­ten­ers nav­i­gate a noisy world and its com­mu­ni­ca­tion challenges.

Categories
Ageing Auditory Neuroscience Clinical relevance Editorial Notes Hearing Loss Neural dynamics Uncategorized

It’s a wrap: The ERC Con­sol­ida­tor Project “Audadapt” has suc­cess­ful­ly ended

Six years in our lab with the age­ing, adapt­ing, lis­ten­ing brain and mind cen­ter-stage have come to a suc­cess­ful close.  Jonas’ ERC Con­sol­ida­tor grant had been grant­ed dur­ing the Audi­to­ry Cog­ni­tion lab’s tenure at the Max Planck Insti­tute in Leipzig orig­i­nal­ly, and it has shaped our start and set­tling-in at the Uni­ver­si­ty of Lübeck ever since 2016.

Jonas: “In total almost 500 ses­sions of behav­iour, EEG and fMRI record­ed; more than 160 brave Lübeck folks and their brains fol­lowed lon­gi­tu­di­nal­ly over two years; 25 pub­li­ca­tions put out; and not least two PhDs fin­ished and five post­doc careers kick­start­ed — I am very grate­ful for the help of all these peo­ple, my host Insti­tu­tion Uni­ver­si­ty of Lübeck and the Euro­pean Research Coun­cil (ERC) hav­ing made this all hap­pen. Thank you all.”

All data will be or are already pub­licly avail­able on OSF, and we will update our ded­i­cat­ed “AUDADAPT” project page once the final report is in.

Categories
Ageing Auditory Cortex Auditory Neuroscience EEG / MEG Hearing Loss Neural Filters Papers Publications

New paper in Nature Com­mu­ni­ca­tions by Tune et al.

We are very excit­ed to share that Oble­ser­lab post­doc Sarah Tune has a new paper in Nature Com­mu­ni­ca­tions. „Neur­al atten­tion­al-fil­ter mech­a­nisms of lis­ten­ing suc­cess in mid­dle-aged and old­er par­tic­i­pants“ is our lat­est and to-date most exten­sive out­put of the lon­gi­tu­di­nal ERC Con­sol­ida­tor project on adap­tive lis­ten­ing in age­ing indi­vid­ual (AUDADAPT).

This co-pro­duc­tion with cur­rent (Mohsen Alavash and Jonas Obleser) and for­mer (Lorenz Fiedler) Oble­ser­lab mem­bers, takes an in-depth and inte­gra­tive look at how two of the most exten­sive­ly stud­ied neu­ro­bi­o­log­i­cal atten­tion­al-fil­ter imple­men­ta­tions, alpha pow­er lat­er­al­iza­tion and selec­tive neur­al speech track­ing, relate to one anoth­er and to lis­ten­ing sucess.

Lever­ag­ing our large, rep­re­sen­ta­tive sam­ple of aging lis­ten­ers (N=155, 39–80 years), we show that both neur­al fil­ter imple­men­tatins are robust­ly mod­u­lat­ed by atten­tion but oper­ate sur­prins­ing­ly inde­pen­dent of one another.

In a series of sophis­ti­cat­ed sin­gle-tri­al lin­ear mod­els that include vari­a­tion in neur­al fil­ter strength with­in and between indi­vid­u­als, we demon­strate how the pref­er­en­tial neur­al track­ing of attend­ed ver­sus ignored speech but not alpha lat­er­al­iza­tion boosts lis­ten­ing success.

To learn more, the paper is avail­able here.

Categories
Ageing EEG / MEG fMRI Papers Publications

New Per­spec­tive paper in Neu­ron by Waschke et al.

We are excit­ed to share that for­mer Oble­ser­lab PhD stu­dent Leo Waschke, togeth­er with his new (Doug Gar­rett, Niels Kloost­er­man) and old (Jonas Obleser) lab has pub­lished an in-depth per­spec­tive piece in Neu­ron, with the provoca­tive title “Behav­ior need neur­al vari­abil­i­ty”.
Our arti­cle is essen­tial­ly a long and exten­sive trib­ute to the “sec­ond moment” of neur­al activ­i­ty, in sta­tis­ti­cal terms, essen­tial­ly: Vari­abil­i­ty — be it quan­ti­fied as vari­ance, entropy, or spec­tral slope — is the long-neglect­ed twin of aver­ages, and it holds great promise in under­stand­ing neur­al states (how does neur­al activ­i­ty dif­fer from one moment to the next?) and traits (how do indi­vid­u­als dif­fer from each other?).
Con­grat­u­la­tions, Leo!